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PEPTIQA BIOTECHMOTS-c10 mgPurity 8% · RUO

Excellent

Rating 5.0 / 5 — early quality score

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MOTS-c

10 mg8% purityLot #MOTSC-2026-001

SKU of selected dimension: PEP-MOTS-10MG

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a 16-amino-acid peptide encoded directly within mitochondrial DNA. First described in 2015 by Dr. Changhan David Lee and colleagues at the University of Southern California, it belongs to a unique class of mitochondrial-derived signaling peptides. Unlike conventional peptides encoded by nuclear DNA, MOTS-c functions as a communication molecule that conveys signals from mitochondria back to the nucleus. Its biological activity is primarily linked to activation of the AMPK (AMP-activated protein kinase) pathway and modulation of the folate-methionine metabolic network, both of which play central roles in cellular energy regulation. Research published in *Cell Metabolism* identified MOTS-c as a potential “exercise mimetic” because it stimulates several metabolic adaptations normally associated with physical activity, including enhanced glucose utilization, increased fatty acid oxidation, and improved mitochondrial biogenesis.
€143.96incl. VAT
✅ In Stock (40)

Volume pricing

QuantityUnit priceSavings
1 vial143.96 €—
3 vials (−7%)134.20 €−7%
5 vials (−12%)126.88 €−12%
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Research Profile

MOTS-c — scientific profile

Content is for educational and research purposes. Research Use Only.

  • 📌 Table of Contents
  • [1. What Is MOTS-c](#-what-is-mots-c)
  • [2. Clinical Studies & Results](#-clinical-studies--results)
  • [3. Key Benefits](#-key-benefits)
  • [4. Possible Side Effects](#-possible-side-effects)
  • [5. Ideal Research Applications](#-ideal-for)
  • [6. Technical Parameters](#-technical-parameters-of-the-mots-c-peptide)
  • [7. Laboratory Safety & Disclaimer](#-laboratory-reagent--for-research-purposes-only)
  • MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a 16-amino-acid peptide encoded directly within mitochondrial DNA. First described in 2015 by Dr. Changhan David Lee and colleagues at the University of Southern California, it belongs to a unique class of mitochondrial-derived signaling peptides. Unlike conventional peptides encoded by nuclear DNA, MOTS-c functions as a communication molecule that conveys signals from mitochondria back to the nucleus.
  • Its biological activity is primarily linked to activation of the AMPK (AMP-activated protein kinase) pathway and modulation of the folate-methionine metabolic network, both of which play central roles in cellular energy regulation. Research published in Cell Metabolism identified MOTS-c as a potential “exercise mimetic” because it stimulates several metabolic adaptations normally associated with physical activity, including enhanced glucose utilization, increased fatty acid oxidation, and improved mitochondrial biogenesis.

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